Occludin-Knockout Human Hepatic Huh7.5.1-8-Derived Cells Are Completely Resistant to Hepatitis C Virus Infection
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منابع مشابه
Ceacam1a-/- mice are completely resistant to infection by murine coronavirus mouse hepatitis virus A59.
CEACAM1a glycoproteins are members of the immunoglobulin (Ig) superfamily and the carcinoembryonic antigen family. Isoforms expressing either two or four alternatively spliced Ig-like domains in mice have been found in a number of epithelial, endothelial, or hematopoietic tissues. CEACAM1a functions as an intercellular adhesion molecule, an angiogenic factor, and a tumor cell growth inhibitor. ...
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Ceacam1a / Mice Are Completely Resistant to Infection by Murine Coronavirus Mouse Hepatitis Virus A59 Erin Hemmila, Claire Turbide, Melanie Olson, Serge Jothy, Kathryn V. Holmes,† and Nicole Beauchemin*† Department of Microbiology, University of Colorado Health Sciences Center, Denver, Colorado, and McGill Cancer Centre and Departments of Biochemistry, Medicine, and Oncology, McGill University,...
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Background and Aims: Many studies have provided evidence for the role of hepatitis B and C viruses in the development of liver cancer. Although the routine treatment is available for both conditions, no definite guideline is available to treat patients dually infected with HBV and HCV. This study was performed to determine the frequency of HBV/HCV-coinfection in Mashhad, North-East of Iran. Mat...
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Background and Objective: Although transfusion therapy has lead to great improvement in longevity for hemophiliacs, but there have been tragic setbacks especially from transmission of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) .HIV was reported to increase the rate of HCV-related liver failure by 4.2 times. In this study, we aimed to determine the seroprevalence of HIV an...
متن کاملTight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection.
A tight junction (TJ) protein, claudin-1 (CLDN1), was identified recently as a key factor for hepatitis C virus (HCV) entry. Here, we show that another TJ protein, occludin, is also required for HCV entry. Mutational study of CLDN1 revealed that its tight junctional distribution plays an important role in mediating viral entry. Together, these data support the model in which HCV enters liver ce...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2016
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.b15-01023